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In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions.

Abstract

Using a monoclonal antibody, anti-Ta1, that identifies antigen-activated T lymphocytes in vitro, we sought to identify activated T lymphocytes in leprosy skin lesions. Greater numbers of Ta1 positive T lymphocytes were observed in tuberculoid leprosy, lepromin skin tests, and reversal reactions as compared with lepromatous leprosy or erythema nodosum leprosum (ENL) (p less than 0.001). With a double-staining technique, we found that the majority of these activated T lymphocytes were of the helper/inducer phenotype. No differences of Ta1 positive lymphocytes were observed in the peripheral blood. The defective cell-mediated immune response in lepromatous and ENL patients correlates with, and may be related to the failure of T-helper/inducer activation or proliferation in the presence of Mycobacterium leprae.

More information

Type
Journal Article
Author
Shen J Y
Hofman F M
Gunter J R
Modlin R L
Rea T H
Year of Publication
1987
Journal
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
Volume
55
Issue
3
Number of Pages
494-8
Date Published
1987 Sep
Language
eng
ISSN Number
0148-916X
Alternate Journal
Int. J. Lepr. Other Mycobact. Dis.
Publication Language
eng

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