@article{9697, keywords = {Antibodies, Monoclonal, Antigens, Surface, Erythema Nodosum, Humans, Immunity, Cellular, Immunoenzyme Techniques, leprosy, Lymphocyte Activation, Mycobacterium leprae, Skin, Staining and Labeling, T-Lymphocytes, T-Lymphocytes, Helper-Inducer, Tumor Necrosis Factor Receptor Superfamily, Member 7}, author = {Shen J Y and Hofman F M and Gunter J R and Modlin R L and Rea T H}, title = {In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions.}, abstract = {

Using a monoclonal antibody, anti-Ta1, that identifies antigen-activated T lymphocytes in vitro, we sought to identify activated T lymphocytes in leprosy skin lesions. Greater numbers of Ta1 positive T lymphocytes were observed in tuberculoid leprosy, lepromin skin tests, and reversal reactions as compared with lepromatous leprosy or erythema nodosum leprosum (ENL) (p less than 0.001). With a double-staining technique, we found that the majority of these activated T lymphocytes were of the helper/inducer phenotype. No differences of Ta1 positive lymphocytes were observed in the peripheral blood. The defective cell-mediated immune response in lepromatous and ENL patients correlates with, and may be related to the failure of T-helper/inducer activation or proliferation in the presence of Mycobacterium leprae.

}, year = {1987}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {55}, pages = {494-8}, month = {1987 Sep}, issn = {0148-916X}, language = {eng}, }