TY - JOUR
KW - Antibodies, Monoclonal
KW - Antigens, Surface
KW - Erythema Nodosum
KW - Humans
KW - Immunity, Cellular
KW - Immunoenzyme Techniques
KW - leprosy
KW - Lymphocyte Activation
KW - Mycobacterium leprae
KW - Skin
KW - Staining and Labeling
KW - T-Lymphocytes
KW - T-Lymphocytes, Helper-Inducer
KW - Tumor Necrosis Factor Receptor Superfamily, Member 7
AU - Shen J Y
AU - Hofman F M
AU - Gunter J R
AU - Modlin R L
AU - Rea T H
AB - <p>Using a monoclonal antibody, anti-Ta1, that identifies antigen-activated T lymphocytes in vitro, we sought to identify activated T lymphocytes in leprosy skin lesions. Greater numbers of Ta1 positive T lymphocytes were observed in tuberculoid leprosy, lepromin skin tests, and reversal reactions as compared with lepromatous leprosy or erythema nodosum leprosum (ENL) (p less than 0.001). With a double-staining technique, we found that the majority of these activated T lymphocytes were of the helper/inducer phenotype. No differences of Ta1 positive lymphocytes were observed in the peripheral blood. The defective cell-mediated immune response in lepromatous and ENL patients correlates with, and may be related to the failure of T-helper/inducer activation or proliferation in the presence of Mycobacterium leprae.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2443587?dopt=Abstract
DA - 1987 Sep
IS - 3
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>Using a monoclonal antibody, anti-Ta1, that identifies antigen-activated T lymphocytes in vitro, we sought to identify activated T lymphocytes in leprosy skin lesions. Greater numbers of Ta1 positive T lymphocytes were observed in tuberculoid leprosy, lepromin skin tests, and reversal reactions as compared with lepromatous leprosy or erythema nodosum leprosum (ENL) (p less than 0.001). With a double-staining technique, we found that the majority of these activated T lymphocytes were of the helper/inducer phenotype. No differences of Ta1 positive lymphocytes were observed in the peripheral blood. The defective cell-mediated immune response in lepromatous and ENL patients correlates with, and may be related to the failure of T-helper/inducer activation or proliferation in the presence of Mycobacterium leprae.</p>
PY - 1987
SP - 494
EP - 8
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions.
VL - 55
SN - 0148-916X
ER -