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Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.

Abstract
Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.

More information

Type
Journal Article
Author
Messias-Reason I
Kremsner P G
Kun J F J
Year of Publication
2009
Journal
The Journal of infectious diseases
Volume
199
Issue
6
Number of Pages
801-4
Date Published
03/2009
Language
eng
Call Number
DEMESSIASREASON2009
DOI
10.1086/597070
Alternate Journal
J. Infect. Dis.
Publication Language
eng