TY - JOUR
KW - Full text online
KW - Reference Values
KW - Promoter Regions, Genetic
KW - Polymorphism, Genetic
KW - leprosy
KW - Lectins
KW - Humans
KW - Haplotypes
KW - Genes, Recessive
KW - Genes, Dominant
KW - Exons
KW - DNA Primers
KW - Chromosome Mapping
AU - Messias-Reason LJT
AU - Kremsner P G
AU - Kun J F J
AB - Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19434912?dopt=Abstract
CN - DEMESSIASREASON2009
DA - 03/2009 
DO - 10.1086/597070
IS - 6
J2 - J. Infect. Dis.
LA - eng
N2 - Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.
PY - 2009
SP - 801
EP - 4
T2 - The Journal of infectious diseases
TI - Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.
UR - http://jid.oxfordjournals.org/content/199/6/801.full.pdf+html?sid=8a8ead85-5077-4a69-b231-c37ff1012c32
VL - 199
ER -