01572nas a2200325   4500000000100000008004100001260001300042653002100055653002100076653003000097653002600127653001200153653001200165653001100177653001500188653002100203653002000224653001000244653001600254653002300270100002300293700001700316700001400333245009700347856010700444300001000551490000800561050002400569520065300593       2009                            d  c03/2009 10aFull text online10aReference Values10aPromoter Regions, Genetic10aPolymorphism, Genetic10aleprosy10aLectins10aHumans10aHaplotypes10aGenes, Recessive10aGenes, Dominant10aExons10aDNA Primers10aChromosome Mapping1 aMessias-Reason LJT1 aKremsner P G1 aKun J F J00aFunctional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.  uhttp://jid.oxfordjournals.org/content/199/6/801.full.pdf+html?sid=8a8ead85-5077-4a69-b231-c37ff1012c32  a801-40 v199  aDEMESSIASREASON20093 aHost factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.