@article{23512,
  keywords = {Full text online, Reference Values, Promoter Regions, Genetic, Polymorphism, Genetic, leprosy, Lectins, Humans, Haplotypes, Genes, Recessive, Genes, Dominant, Exons, DNA Primers, Chromosome Mapping},
  author = {Messias-Reason LJT and Kremsner P G and Kun J F J},
  title = {Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.},
  abstract = {Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.},
  year = {2009},
  journal = {The Journal of infectious diseases},
  volume = {199},
  pages = {801-4},
  month = {03/2009 },
  url = {http://jid.oxfordjournals.org/content/199/6/801.full.pdf+html?sid=8a8ead85-5077-4a69-b231-c37ff1012c32},
  doi = {10.1086/597070},
  language = {eng},
}