|Title||Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.|
|Publication Type||Journal Article|
|Authors||Furukawa F, Kashihara M, Imamura S, Ohshio G, Hamashima Y|
|Abbrev. Journal||Arch. Dermatol. Res.|
|Journal||Archives of dermatological research|
|Year of Publication||1986|
|Keywords||Antigens, Nuclear, Autoantibodies, Cardiolipins, Cross Reactions, DNA, DNA, Single-Stranded, Humans, Leprosy, Nucleoproteins|
Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with single-stranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.