Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.

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TitleEvaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.
Publication TypeJournal Article
AuthorsFurukawa F, Kashihara M, Imamura S, Ohshio G, Hamashima Y
Abbrev. JournalArch. Dermatol. Res.
JournalArchives of dermatological research
Year of Publication1986
Volume278
Issue4
Pagination317-9
Publication Languageeng
KeywordsAntigens, Nuclear, Autoantibodies, Cardiolipins, Cross Reactions, DNA, DNA, Single-Stranded, Humans, Leprosy, Nucleoproteins
Abstract

Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with single-stranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/3740940?dopt=Abstract

DOI10.1007/bf00407745

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