@article{11716, keywords = {Antigens, Nuclear, Autoantibodies, Cardiolipins, Cross Reactions, DNA, DNA, Single-Stranded, Humans, leprosy, Nucleoproteins}, author = {Furukawa F and Kashihara M and Imamura S and Ohshio G and Hamashima Y}, title = {Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.}, abstract = {

Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with single-stranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.

}, year = {1986}, journal = {Archives of dermatological research}, volume = {278}, pages = {317-9}, month = {1986}, issn = {0340-3696}, doi = {10.1007/bf00407745}, language = {eng}, }