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Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.

Abstract
Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population.

More information

Type
Journal Article
Author
Escamilla-Tilch M
Torres-Carrillo NM
Payan RR
Aguilar-Medina M
Salazar MI
Fafutis-Morris M
Arenas-Guzman R
Estrada-Parra S
Estrada-Garcia I
Granados J
Year of Publication
2013
Journal
Biomedical reports
Volume
1
Issue
6
Number of Pages
945-949
Date Published
2013 Nov
Language
eng
ISSN Number
2049-9434
Call Number
ESCAMILLA - TILCH 2013
DOI
10.3892/br.2013.167
Alternate Journal
Biomed Rep
Publication Language
eng