TY - JOUR
KW - leprosy
KW - Mexico
KW - Polymorphism
KW - Prevention
AU - Escamilla-Tilch M
AU - Torres-Carrillo NM
AU - Payan RR
AU - Aguilar-Medina M
AU - Salazar MI
AU - Fafutis-Morris M
AU - Arenas-Guzmán R
AU - Estrada-Parra S
AU - Estrada-Garcia I
AU - Granados J
AB - Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population.
BT - Biomedical reports
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24649058?dopt=Abstract
CN - ESCAMILLA - TILCH 2013
DA - 2013 Nov
DO - 10.3892/br.2013.167
IS - 6
J2 - Biomed Rep
LA - eng
N2 - Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population.
PY - 2013
SP - 945
EP - 949
T2 - Biomedical reports
TI - Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917101/pdf/br-01-06-0945.pdf
VL - 1
SN - 2049-9434
ER -