02126nas a2200313   4500000000100000008004100001260001300042653001200055653001100067653001700078653001500095100002200110700002300132700001300155700002100168700001500189700002100204700002100225700002000246700002100266700001500287245010900302856007800411300001200489490000600501050002700507520126400534022001401798       2013                            d  c2013 Nov10aleprosy10aMexico10aPolymorphism10aPrevention1 aEscamilla-Tilch M1 aTorres-Carrillo NM1 aPayan RR1 aAguilar-Medina M1 aSalazar MI1 aFafutis-Morris M1 aArenas-Guzmán R1 aEstrada-Parra S1 aEstrada-Garcia I1 aGranados J00aAssociation of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917101/pdf/br-01-06-0945.pdf  a945-9490 v1  aESCAMILLA - TILCH 20133 aDespite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population.  a2049-9434