@article{24758,
  keywords = {leprosy, Mexico, Polymorphism, Prevention},
  author = {Escamilla-Tilch M and Torres-Carrillo NM and Payan RR and Aguilar-Medina M and Salazar MI and Fafutis-Morris M and Arenas-Guzmán R and Estrada-Parra S and Estrada-Garcia I and Granados J},
  title = {Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.},
  abstract = {Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population.},
  year = {2013},
  journal = {Biomedical reports},
  volume = {1},
  pages = {945-949},
  month = {2013 Nov},
  issn = {2049-9434},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917101/pdf/br-01-06-0945.pdf},
  doi = {10.3892/br.2013.167},
  language = {eng},
}