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Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.

Abstract

Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.

More information

Type
Journal Article
Author
Nathan C
Squires K
Griffo W
Levis W
Varghese M
Job C K
Nusrat A R
Sherwin S
Rappoport S
Sanchez E
Year of Publication
1990
Journal
The Journal of experimental medicine
Volume
172
Issue
5
Number of Pages
1509-12
Date Published
1990 Nov 01
Language
eng
ISSN Number
0022-1007
DOI
10.1084/jem.172.5.1509
Alternate Journal
J. Exp. Med.
Publication Language
eng

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