@article{9265,
  keywords = {Adult, Aged, Antigens, CD, Bacterial Infections, Dose-Response Relationship, Drug, Epidermis, Female, Histocompatibility Antigens Class II, Humans, Injections, Intramuscular, Interferon-gamma, Leprosy, lepromatous, Leukocytes, Mononuclear, Male, Middle Aged, Neurons, Afferent, Recombinant Proteins},
  author = {Nathan C and Squires K and Griffo W and Levis W and Varghese M and Job C K and Nusrat A R and Sherwin S and Rappoport S and Sanchez E},
  title = {Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.},
  abstract = {<p>Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.</p>},
  year = {1990},
  journal = {The Journal of experimental medicine},
  volume = {172},
  pages = {1509-12},
  month = {1990 Nov 01},
  issn = {0022-1007},
  doi = {10.1084/jem.172.5.1509},
  language = {eng},
}