TY - JOUR
KW - Adult
KW - Aged
KW - Antigens, CD
KW - Bacterial Infections
KW - Dose-Response Relationship, Drug
KW - Epidermis
KW - Female
KW - Histocompatibility Antigens Class II
KW - Humans
KW - Injections, Intramuscular
KW - Interferon-gamma
KW - Leprosy, lepromatous
KW - Leukocytes, Mononuclear
KW - Male
KW - Middle Aged
KW - Neurons, Afferent
KW - Recombinant Proteins
AU - Nathan C
AU - Squires K
AU - Griffo W
AU - Levis W
AU - Varghese M
AU - Job C K
AU - Nusrat A R
AU - Sherwin S
AU - Rappoport S
AU - Sanchez E
AB - <p>Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.</p>
BT - The Journal of experimental medicine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2121891?dopt=Abstract
DA - 1990 Nov 01
DO - 10.1084/jem.172.5.1509
IS - 5
J2 - J. Exp. Med.
LA - eng
N2 - <p>Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.</p>
PY - 1990
SP - 1509
EP - 12
T2 - The Journal of experimental medicine
TI - Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.
VL - 172
SN - 0022-1007
ER -