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Publication

Reversion of the downhill course of active lepromatous leprosy by repeated transfusions of fresh blood, donated by healthy but lepromin positive patients.

Abstract

Earlier studies of immunologic reconstitution therapy of active lepromatous leprosy patients by repeated infusions of viable allogeneic blood lymphocytes indicated a beneficial effect. In order to avoid cell separation and its associated risks, we attempted to transfer immunity passively into seven seriously ill lepromatous patients by repeated transfusions of fresh blood donated by healthy, but tuberculin and lepromin positive, subjects. The results showed clinical improvement in some cases with the elimination of Mycobacterium leprae, histological reversion and return of immunologic responsiveness.

More information

Type
Journal Article
Author
Saha K
Mittal M M
Maheswari H B
Year of Publication
1982
Journal
Transfusion
Volume
22
Issue
2
Number of Pages
134-7
Date Published
1982 Mar-Apr
Language
eng
ISSN Number
0041-1132
DOI
10.1046/j.1537-2995.1982.22282177120.x
Alternate Journal
Transfusion
Publication Language
eng