01438nas a2200313   4500000000100000008004100001260001700042653001000059653002200069653002500091653002100116653001100137653001100148653001300159653001200172653000900184653001600193653002500209653001700234653002000251100001100271700001500282700001800297245015900315300001000474490000700484520061900491022001401110       1982                            d  c1982 Mar-Apr10aAdult10aBlood Transfusion10aDinitrochlorobenzene10aErythema Nodosum10aFemale10aHumans10aLepromin10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aTime Factors10aTuberculin Test1 aSaha K1 aMittal M M1 aMaheswari H B00aReversion of the downhill course of active lepromatous leprosy by repeated transfusions of fresh blood, donated by healthy but lepromin positive patients.  a134-70 v223 a<p>Earlier studies of immunologic reconstitution therapy of active lepromatous leprosy patients by repeated infusions of viable allogeneic blood lymphocytes indicated a beneficial effect. In order to avoid cell separation and its associated risks, we attempted to transfer immunity passively into seven seriously ill lepromatous patients by repeated transfusions of fresh blood donated by healthy, but tuberculin and lepromin positive, subjects. The results showed clinical improvement in some cases with the elimination of Mycobacterium leprae, histological reversion and return of immunologic responsiveness.</p>  a0041-1132