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Publication

The production and preliminary investigation of Burulin, a new skin test reagent for Mycobacterium ulcerans infection.

Abstract

The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

More information

Type
Journal Article
Author
Stanford J L
Revill W D
Gunthorpe W J
Grange J M
Year of Publication
1975
Journal
Journal of hygiene (Lond)
Volume
74
Issue
1
Number of Pages
7-16
Date Published
1975 Feb
Language
eng
ISSN Number
0022-1724
Alternate Journal
J Hyg (Lond)
Publication Language
eng
Regional focus