TY - JOUR KW - Uganda KW - Tuberculosis KW - Tuberculin Test KW - Tropical Medicine KW - Skin Tests KW - Mycobacterium Infections KW - Mycobacterium KW - leprosy KW - Hypersensitivity, Delayed KW - Humans KW - Democratic Republic of the Congo KW - Child KW - Antigens, Bacterial AU - Stanford J L AU - Revill W D AU - Gunthorpe W J AU - Grange J M AB -

The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

BT - Journal of hygiene (Lond) C1 - http://www.ncbi.nlm.nih.gov/pubmed/1054061?dopt=Abstract DA - 1975 Feb IS - 1 J2 - J Hyg (Lond) LA - eng N2 -

The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

PY - 1975 SP - 7 EP - 16 T2 - Journal of hygiene (Lond) TI - The production and preliminary investigation of Burulin, a new skin test reagent for Mycobacterium ulcerans infection. UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131542/pdf/jhyg00070-0015.pdf VL - 74 SN - 0022-1724 ER -