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Publication

Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy.

Abstract

The genotypes of Mycobacterium leprae isolates originating from Mexico, Peru and Paraguay were analysed for the polymorphism of short tandem repeats in the rpoT gene. The genotype with four copies of the six-base tandem repeats in the rpoT gene was prominently predominant in Mexico, but the genotype of all isolates from Peru and Paraguay contained three copies of the six-base tandem repeats. These obvious different distributions might reflect the spread of leprosy by the different strains of M. leprae harboured by the various human races that moved to the American continent, as has been demonstrated in other infectious diseases.

More information

Type
Journal Article
Author
Matsuoka M
Zhang L
Morris MF
Legua P
Wiens C
Year of Publication
2005
Journal
FEMS microbiology letters
Volume
243
Issue
2
Number of Pages
311-5
Date Published
2005 Feb 15
Language
eng
ISSN Number
0378-1097
DOI
10.1016/j.femsle.2004.12.031
Alternate Journal
FEMS Microbiol. Lett.
Publication Language
eng