Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy.

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TitlePolymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy.
Publication TypeJournal Article
AuthorsMatsuoka M, Zhang L, Morris MF, Legua P, Wiens C
Abbrev. JournalFEMS Microbiol. Lett.
JournalFEMS microbiology letters
Year of Publication2005
Volume243
Issue2
Pagination311-5
Publication Languageeng
KeywordsBacterial Proteins, Humans, Leprosy, Mexico, Mycobacterium leprae, Paraguay, Peru, Polymorphism, Genetic, Sigma Factor
Abstract

The genotypes of Mycobacterium leprae isolates originating from Mexico, Peru and Paraguay were analysed for the polymorphism of short tandem repeats in the rpoT gene. The genotype with four copies of the six-base tandem repeats in the rpoT gene was prominently predominant in Mexico, but the genotype of all isolates from Peru and Paraguay contained three copies of the six-base tandem repeats. These obvious different distributions might reflect the spread of leprosy by the different strains of M. leprae harboured by the various human races that moved to the American continent, as has been demonstrated in other infectious diseases.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/15686829?dopt=Abstract

DOI10.1016/j.femsle.2004.12.031
Link to full texthttp://onlinelibrary.wiley.com/doi/10.1016/j.femsle.2004.12.031/pdf