01487nas a2200301   4500000000100000008004100001260001600042653002300058653001100081653001200092653001100104653002500115653001300140653000900153653002600162653001700188100001500205700001200220700001400232700001200246700001200258245016300270856007200433300001000505490000800515520064800523022001401171       2005                            d  c2005 Feb 1510aBacterial Proteins10aHumans10aleprosy10aMexico10aMycobacterium leprae10aParaguay10aPeru10aPolymorphism, Genetic10aSigma Factor1 aMatsuoka M1 aZhang L1 aMorris MF1 aLegua P1 aWiens C00aPolymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy.  uhttp://onlinelibrary.wiley.com/doi/10.1016/j.femsle.2004.12.031/pdf  a311-50 v2433 a<p>The genotypes of Mycobacterium leprae isolates originating from Mexico, Peru and Paraguay were analysed for the polymorphism of short tandem repeats in the rpoT gene. The genotype with four copies of the six-base tandem repeats in the rpoT gene was prominently predominant in Mexico, but the genotype of all isolates from Peru and Paraguay contained three copies of the six-base tandem repeats. These obvious different distributions might reflect the spread of leprosy by the different strains of M. leprae harboured by the various human races that moved to the American continent, as has been demonstrated in other infectious diseases.</p>  a0378-1097