The genotypes of Mycobacterium leprae isolates originating from Mexico, Peru and Paraguay were analysed for the polymorphism of short tandem repeats in the rpoT gene. The genotype with four copies of the six-base tandem repeats in the rpoT gene was prominently predominant in Mexico, but the genotype of all isolates from Peru and Paraguay contained three copies of the six-base tandem repeats. These obvious different distributions might reflect the spread of leprosy by the different strains of M. leprae harboured by the various human races that moved to the American continent, as has been demonstrated in other infectious diseases.
BT - FEMS microbiology letters C1 - http://www.ncbi.nlm.nih.gov/pubmed/15686829?dopt=Abstract DA - 2005 Feb 15 DO - 10.1016/j.femsle.2004.12.031 IS - 2 J2 - FEMS Microbiol. Lett. LA - eng N2 -The genotypes of Mycobacterium leprae isolates originating from Mexico, Peru and Paraguay were analysed for the polymorphism of short tandem repeats in the rpoT gene. The genotype with four copies of the six-base tandem repeats in the rpoT gene was prominently predominant in Mexico, but the genotype of all isolates from Peru and Paraguay contained three copies of the six-base tandem repeats. These obvious different distributions might reflect the spread of leprosy by the different strains of M. leprae harboured by the various human races that moved to the American continent, as has been demonstrated in other infectious diseases.
PY - 2005 SP - 311 EP - 5 T2 - FEMS microbiology letters TI - Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy. UR - http://onlinelibrary.wiley.com/doi/10.1016/j.femsle.2004.12.031/pdf VL - 243 SN - 0378-1097 ER -