Publication

Long lasting BCG protection against leprosy.

Rodrigues L, Kerr-Pontes LRS, Frietas MVC, et al. Vaccine. 2007; 25 (39-40) : 6842-4.

Abstract

BACKGROUND: BCG vaccine protects against leprosy.

OBJECTIVES: Estimate BCG protection against leprosy by age by age.

METHODS: A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.

RESULTS: BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.

CONCLUSIONS: BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.

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Journal Article

Author

Rodrigues L

Kerr-Pontes LRS

Frietas MVC

Barreto ML