TY - JOUR
KW - Adolescent
KW - Adult
KW - Age Factors
KW - BCG Vaccine
KW - Brazil
KW - Case-Control Studies
KW - Humans
KW - Incidence
KW - leprosy
KW - Mycobacterium leprae
KW - Sensitivity and Specificity
KW - Time Factors
KW - Treatment Outcome
KW - Vaccination
AU - Rodrigues L
AU - Kerr-Pontes LRS
AU - Frietas MVC
AU - Barreto ML
AB - <p><b>BACKGROUND: </b>BCG vaccine protects against leprosy.</p><p><b>OBJECTIVES: </b>Estimate BCG protection against leprosy by age by age.</p><p><b>METHODS: </b>A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.</p><p><b>RESULTS: </b>BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.</p><p><b>CONCLUSIONS: </b>BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/17728023?dopt=Abstract
CN - RODRIGUES 2007
DA - 2007 Sep 28
DO - 10.1016/j.vaccine.2007.07.032
IS - 39-40
J2 - Vaccine
LA - eng
N2 - <p><b>BACKGROUND: </b>BCG vaccine protects against leprosy.</p><p><b>OBJECTIVES: </b>Estimate BCG protection against leprosy by age by age.</p><p><b>METHODS: </b>A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.</p><p><b>RESULTS: </b>BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.</p><p><b>CONCLUSIONS: </b>BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.</p>
PY - 2007
SP - 6842
EP - 4
T2 - Vaccine
TI - Long lasting BCG protection against leprosy.
VL - 25
SN - 0264-410X
ER -