@article{7578, keywords = {Adolescent, Adult, Age Factors, BCG Vaccine, Brazil, Case-Control Studies, Humans, Incidence, leprosy, Mycobacterium leprae, Sensitivity and Specificity, Time Factors, Treatment Outcome, Vaccination}, author = {Rodrigues L and Kerr-Pontes LRS and Frietas MVC and Barreto ML}, title = {Long lasting BCG protection against leprosy.}, abstract = {

BACKGROUND: BCG vaccine protects against leprosy.

OBJECTIVES: Estimate BCG protection against leprosy by age by age.

METHODS: A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.

RESULTS: BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.

CONCLUSIONS: BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.

}, year = {2007}, journal = {Vaccine}, volume = {25}, pages = {6842-4}, month = {2007 Sep 28}, issn = {0264-410X}, doi = {10.1016/j.vaccine.2007.07.032}, language = {eng}, }