|Title||Leprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort.|
|Publication Type||Journal Article|
|Authors||Menezes VM, Sales AM, Illarramendi X, Miranda A, Gonçalves Morgado M, Gutierrez-Galhardo MC, Nunes Sarno E, da Costa Nery JA|
|Journal||AIDS (London, England)|
|Year of Publication||2009|
|Keywords||Adult, Antiretroviral Therapy, Highly Active, Cohort Studies, Female, HIV Infections, Humans, Immune Reconstitution Inflammatory Syndrome, Leprosy, Male, Middle Aged, Young Adult|
Several case reports have demonstrated that the immune reconstitution inflammatory syndrome induces reversal reaction in HIV and leprosy-coinfected patients. The present study describes 10 cases of immune reconstitution inflammatory-associated reversal reaction. The patients evolved satisfactorily despite presenting a more severe form of the disease and the fact that three required an additional use of corticoids. The present study, the largest case series published to date, demonstrates that leprosy reaction is a manifestation of immune reconstitution.