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Leprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapy.

Abstract

Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral therapy. The lesions improved after a few weeks of multidrug therapy for leprosy. Mycobacterium leprae was confirmed by polymerase chain reaction analysis of blood in case 1 and of a biopsy sample in case 2. Neither Mycobacterium avium complex nucleic acid, which is usually associated with immune restoration syndrome, nor mycobacterial cutaneous manifestations were detected in either case.

More information

Type
Journal Article
Author
Pignataro P
Rocha SA
Nery J A C
Miranda A
Sales A M
Ferrreira H
Valentim V
Suffys P N
Year of Publication
2004
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Volume
23
Issue
5
Number of Pages
408-11
Date Published
2004 May
Language
eng
ISSN Number
0934-9723
DOI
10.1007/s10096-004-1131-7
Alternate Journal
Eur. J. Clin. Microbiol. Infect. Dis.
Publication Language
eng

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