01570nas a2200361   4500000000100000008004100001260001300042653004200055653001000097653004200107653001100149653001900160653001100179653003000190653001700220653001200237653000900249653001600258653002500274100001600299700001300315700001500328700001400343700001400357700001600371700001500387700001500402245012300417300001100540490000700551520063600558022001401194       2004                            d  c2004 May10aAIDS-Related Opportunistic Infections10aAdult10aAntiretroviral Therapy, Highly Active10aFemale10aHIV Infections10aHumans10aHypersensitivity, Delayed10aInflammation10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae1 aPignataro P1 aRocha SA1 aNery J A C1 aMiranda A1 aSales A M1 aFerrreira H1 aValentim V1 aSuffys P N00aLeprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapy.  a408-110 v233 a<p>Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral therapy. The lesions improved after a few weeks of multidrug therapy for leprosy. Mycobacterium leprae was confirmed by polymerase chain reaction analysis of blood in case 1 and of a biopsy sample in case 2. Neither Mycobacterium avium complex nucleic acid, which is usually associated with immune restoration syndrome, nor mycobacterial cutaneous manifestations were detected in either case.</p>  a0934-9723