Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral therapy. The lesions improved after a few weeks of multidrug therapy for leprosy. Mycobacterium leprae was confirmed by polymerase chain reaction analysis of blood in case 1 and of a biopsy sample in case 2. Neither Mycobacterium avium complex nucleic acid, which is usually associated with immune restoration syndrome, nor mycobacterial cutaneous manifestations were detected in either case.
BT - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology C1 - http://www.ncbi.nlm.nih.gov/pubmed/15112073?dopt=Abstract DA - 2004 May DO - 10.1007/s10096-004-1131-7 IS - 5 J2 - Eur. J. Clin. Microbiol. Infect. Dis. LA - eng N2 -Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral therapy. The lesions improved after a few weeks of multidrug therapy for leprosy. Mycobacterium leprae was confirmed by polymerase chain reaction analysis of blood in case 1 and of a biopsy sample in case 2. Neither Mycobacterium avium complex nucleic acid, which is usually associated with immune restoration syndrome, nor mycobacterial cutaneous manifestations were detected in either case.
PY - 2004 SP - 408 EP - 11 T2 - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology TI - Leprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapy. VL - 23 SN - 0934-9723 ER -