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Publication

Leishmanization: use of an old method for evaluation of candidate vaccines against leishmaniasis.

Abstract

To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.

More information

Type
Journal Article
Author
Khamesipour A
Dowlati Y
Asilian A
Hashemi-Fesharki R
Javadi A
Noazin S
Modabber F
Year of Publication
2005
Journal
Vaccine
Volume
23
Issue
28
Number of Pages
3642-8
Date Published
2005 May 25
Language
eng
ISSN Number
0264-410X
DOI
10.1016/j.vaccine.2005.02.015
Alternate Journal
Vaccine
Publication Language
eng