TY - JOUR
KW - Adult
KW - Animals
KW - Humans
KW - Iran
KW - Leishmania major
KW - Leishmaniasis, Cutaneous
KW - Male
KW - Mice
KW - Mice, Inbred BALB C
KW - Middle Aged
KW - Protozoan Vaccines
KW - Skin Tests
KW - Virulence
AU - Khamesipour A
AU - Dowlati Y
AU - Asilian A
AU - Hashemi-Fesharki R
AU - Javadi A
AU - Noazin S
AU - Modabber F
AB - <p>To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15882524?dopt=Abstract
DA - 2005 May 25
DO - 10.1016/j.vaccine.2005.02.015
IS - 28
J2 - Vaccine
LA - eng
N2 - <p>To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.</p>
PY - 2005
SP - 3642
EP - 8
T2 - Vaccine
TI - Leishmanization: use of an old method for evaluation of candidate vaccines against leishmaniasis.
VL - 23
SN - 0264-410X
ER -