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Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.

Abstract

Despite being treatable, leprosy still represents a major public health problem, and many mechanisms that drive leprosy immunopathogenesis still need to be elucidated. B cells play important roles in immune defense, being classified in different subgroups that present distinct roles in the immune response. Here, the profile of B cell subpopulations in peripheral blood of patients with paucibacillary (TT/BT), multibacillary (LL/BL) and erythema nodosum leprosum was analyzed. B cell subpopulations (memory, transition, plasmablasts, and mature B cells) and levels of IgG were analyzed by flow cytometry and ELISA, respectively. It was observed that infection can alter the proportions of B cell subpopulations (increase of mature and decrease of memory B cells) in patients affected by leprosy. This modulation is associated with an increase in total IgG and the patient's clinical condition. Circulating B cells may be acting in the modulation of the immune response in patients with various forms of leprosy, which may reflect the patient's ability to respond to

More information

Type
Journal Article
Author
Nogueira O
Gandini M
Cabral N
de Figueiredo V
Rodrigues-da-Silva R
Lima-Junior J
Pinheiro R
Pereira G
Pessolani M
de Macedo C
Year of Publication
2021
Journal
Frontiers in immunology
Volume
12
Number of Pages
727580
Date Published
01/2021
Language
eng
ISSN Number
1664-3224
DOI
10.3389/fimmu.2021.727580
Alternate Journal
Front Immunol
PMID
34621273
Publication Language
eng