@article{96043,
  keywords = {B cell differentiation, B lymphocytes, Mycobacterium leprae, active immune response, erythema nodosum leprosum},
  author = {Nogueira O and Gandini M and Cabral N and de Figueiredo V and Rodrigues-da-Silva R and Lima-Junior J and Pinheiro R and Pereira GMB and Pessolani M and de Macedo C},
  title = {Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.},
  abstract = {<p>Despite being treatable, leprosy still represents a major public health problem, and many mechanisms that drive leprosy immunopathogenesis still need to be elucidated. B cells play important roles in immune defense, being classified in different subgroups that present distinct roles in the immune response. Here, the profile of B cell subpopulations in peripheral blood of patients with paucibacillary (TT/BT), multibacillary (LL/BL) and erythema nodosum leprosum was analyzed. B cell subpopulations (memory, transition, plasmablasts, and mature B cells) and levels of IgG were analyzed by flow cytometry and ELISA, respectively. It was observed that  infection can alter the proportions of B cell subpopulations (increase of mature and decrease of memory B cells) in patients affected by leprosy. This modulation is associated with an increase in total IgG and the patient's clinical condition. Circulating B cells may be acting in the modulation of the immune response in patients with various forms of leprosy, which may reflect the patient's ability to respond to </p>},
  year = {2021},
  journal = {Frontiers in immunology},
  volume = {12},
  pages = {727580},
  month = {01/2021},
  issn = {1664-3224},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490736/pdf/fimmu-12-727580.pdf},
  doi = {10.3389/fimmu.2021.727580},
  language = {eng},
}