01993nas a2200313   4500000000100000008004100001260001200042653002700054653001800081653002500099653002700124653003000151100001500181700001400196700001300210700002000223700002500243700001800268700001500286700001600301700001600317700001600333245013600349856008100485300001100566490000700577520108100584022001401665       2021                            d  c01/202110aB cell differentiation10aB lymphocytes10aMycobacterium leprae10aactive immune response10aerythema nodosum leprosum1 aNogueira O1 aGandini M1 aCabral N1 ade Figueiredo V1 aRodrigues-da-Silva R1 aLima-Junior J1 aPinheiro R1 aPereira GMB1 aPessolani M1 ade Macedo C00aChanges in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490736/pdf/fimmu-12-727580.pdf  a7275800 v123 a<p>Despite being treatable, leprosy still represents a major public health problem, and many mechanisms that drive leprosy immunopathogenesis still need to be elucidated. B cells play important roles in immune defense, being classified in different subgroups that present distinct roles in the immune response. Here, the profile of B cell subpopulations in peripheral blood of patients with paucibacillary (TT/BT), multibacillary (LL/BL) and erythema nodosum leprosum was analyzed. B cell subpopulations (memory, transition, plasmablasts, and mature B cells) and levels of IgG were analyzed by flow cytometry and ELISA, respectively. It was observed that  infection can alter the proportions of B cell subpopulations (increase of mature and decrease of memory B cells) in patients affected by leprosy. This modulation is associated with an increase in total IgG and the patient's clinical condition. Circulating B cells may be acting in the modulation of the immune response in patients with various forms of leprosy, which may reflect the patient's ability to respond to </p>  a1664-3224