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Publication

Cellular immune response to common mycobacterial antigens in subjects seropositive for Trypanosoma cruzi.

Abstract

The immune response is impaired in the silent stage of Chagas' disease. We used quadruple skin-testing with new tuberculins in 37 adults who were symptom-free but seropositive for Trypanosoma cruzi and in 37 matched seronegative controls. Whereas 19% of controls responded to common mycobacterial antigens, none of the Chagas' seropositive group responded to them (p < 0.006), demonstrating specificity in their unresponsiveness. The enhanced tuberculin reactivity after BCG vaccination in the control group was suppressed in seropositive subjects (p < 0.002). Selective loss of response to common mycobacterial antigens may have implications for the autoimmune pathology of Chagas' disease, and for susceptibility to tuberculosis, leprosy, and HIV disease.

More information

Type
Journal Article
Author
Bottasso O A
Ingledew N
Keni M
Morini J
Pividori J F
Rook G A
Stanford J L
Year of Publication
1994
Journal
Lancet (London, England)
Volume
344
Issue
8936
Number of Pages
1540-1
Date Published
1994 Dec 03
Language
eng
ISSN Number
0140-6736
DOI
10.1016/s0140-6736(94)90351-4
Alternate Journal
Lancet
Publication Language
eng

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