@article{17948,
  keywords = {Adult, Animals, Antigens, Protozoan, Chagas disease, Female, Humans, Immunity, Cellular, Male, Mycobacterium bovis, Skin Tests, Trypanosoma cruzi, Tuberculin Test},
  author = {Bottasso O A and Ingledew N and Keni M and Morini J and Pividori J F and Rook G A and Stanford J L},
  title = {Cellular immune response to common mycobacterial antigens in subjects seropositive for Trypanosoma cruzi.},
  abstract = {<p>The immune response is impaired in the silent stage of Chagas' disease. We used quadruple skin-testing with new tuberculins in 37 adults who were symptom-free but seropositive for Trypanosoma cruzi and in 37 matched seronegative controls. Whereas 19% of controls responded to common mycobacterial antigens, none of the Chagas' seropositive group responded to them (p < 0.006), demonstrating specificity in their unresponsiveness. The enhanced tuberculin reactivity after BCG vaccination in the control group was suppressed in seropositive subjects (p < 0.002). Selective loss of response to common mycobacterial antigens may have implications for the autoimmune pathology of Chagas' disease, and for susceptibility to tuberculosis, leprosy, and HIV disease.</p>},
  year = {1994},
  journal = {Lancet (London, England)},
  volume = {344},
  pages = {1540-1},
  month = {1994 Dec 03},
  issn = {0140-6736},
  doi = {10.1016/s0140-6736(94)90351-4},
  language = {eng},
}