01623nas a2200349   4500000000100000008004100001260001600042653001000058653001200068653002400080653001900104653001100123653001100134653002300145653000900168653002400177653001500201653002200216653002000238100001700258700001500275700001100290700001300301700001700314700001300331700001700344245011000361300001100471490000800482520076900490022001401259       1994                            d  c1994 Dec 0310aAdult10aAnimals10aAntigens, Protozoan10aChagas disease10aFemale10aHumans10aImmunity, Cellular10aMale10aMycobacterium bovis10aSkin Tests10aTrypanosoma cruzi10aTuberculin Test1 aBottasso O A1 aIngledew N1 aKeni M1 aMorini J1 aPividori J F1 aRook G A1 aStanford J L00aCellular immune response to common mycobacterial antigens in subjects seropositive for Trypanosoma cruzi.  a1540-10 v3443 a<p>The immune response is impaired in the silent stage of Chagas' disease. We used quadruple skin-testing with new tuberculins in 37 adults who were symptom-free but seropositive for Trypanosoma cruzi and in 37 matched seronegative controls. Whereas 19% of controls responded to common mycobacterial antigens, none of the Chagas' seropositive group responded to them (p < 0.006), demonstrating specificity in their unresponsiveness. The enhanced tuberculin reactivity after BCG vaccination in the control group was suppressed in seropositive subjects (p < 0.002). Selective loss of response to common mycobacterial antigens may have implications for the autoimmune pathology of Chagas' disease, and for susceptibility to tuberculosis, leprosy, and HIV disease.</p>  a0140-6736