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Ultracytochemical studies of lysosomal function in the macrophages of human leprosy--I.

Abstract

The present study was undertaken to understand the lysosomal status and function in macrophages across the leprosy spectrum, including the reactional states. Acid phosphatase was used as the marker enzyme to demonstrate lysosomes at the electron microscopic level. It was observed that lysosomal morphology was well maintained in the macrophages of tuberculoid, borderline tuberculoid, and borderline tuberculoid leprosy in reaction, while they lost their cellular morphology and cell membrane integrity in lepromatous leprosy and lepromatous leprosy in reaction. The importance of these findings is discussed.

More information

Type
Journal Article
Author
Bharadwaj V P
Sakai M
Ogawa K
NISHIURA M
Year of Publication
1987
Journal
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
Volume
55
Issue
2
Number of Pages
328-32
Date Published
1987 Jun
Language
eng
ISSN Number
0148-916X
Alternate Journal
Int. J. Lepr. Other Mycobact. Dis.
Publication Language
eng

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