01206nas a2200241   4500000000100000008004100001260001300042653001100055653002800066653001200094653001400106653001600120653002500136100001800161700001200179700001200191700001500203245009200218300001100310490000700321520062200328022001400950       1987                            d  c1987 Jun10aHumans10aIntracellular Membranes10aleprosy10aLysosomes10aMacrophages10aMicroscopy, Electron1 aBharadwaj V P1 aSakai M1 aOgawa K1 aNISHIURA M00aUltracytochemical studies of lysosomal function in the macrophages of human leprosy--I.  a328-320 v553 a<p>The present study was undertaken to understand the lysosomal status and function in macrophages across the leprosy spectrum, including the reactional states. Acid phosphatase was used as the marker enzyme to demonstrate lysosomes at the electron microscopic level. It was observed that lysosomal morphology was well maintained in the macrophages of tuberculoid, borderline tuberculoid, and borderline tuberculoid leprosy in reaction, while they lost their cellular morphology and cell membrane integrity in lepromatous leprosy and lepromatous leprosy in reaction. The importance of these findings is discussed.</p>  a0148-916X