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Publication

A study of steroid-induced diabetes mellitus in leprosy.

Abstract

Steroids, while still the most powerful drugs to manage leprosy reactions, predispose some patients to other morbidities such as diabetes, glaucoma, hypertension etc. A prospective cohort study was done in Kolkata, India among leprosy patients in reaction to determine the extent of steroid induced diabetes mellitus (SID). All leprosy patients with type 1 or type 2 reactions or neuritis admitted in 2006 to the Leprosy Mission Hospital in Kolkata, who had no past or current history and whose blood sugars on fasting were <126 mg/dl or postprandial <200 mg/dl were monitored fortnightly while on steroid therapy, estimating blood glucose by a glucometer using standard strips. Of 81 patients, 19 (23.5%) manifested steroid-induced diabetes mellitus. Compared to those who didn't, there were significantly more LL/BL patients with positive BI among SID whose cumulative prednisolone dosage was nearly 9000 mg as compared to half the amount among others. Steroid induced diabetes is a serious complication among leprosy patients treated with prednisolone for reactions requiring careful monitoring for detection and appropriate clinical management.

More information

Type
Journal Article
Author
Papang R
John A S
Abraham S
Rao P S S S
Year of Publication
2009
Journal
Indian journal of leprosy
Volume
81
Issue
3
Number of Pages
125-9
Date Published
2009 Jul-Sep
Language
eng
ISSN Number
0254-9395
Call Number
Infolep Library - available
DOI
10.1136/bmj.c3651
Alternate Journal
Indian J Lepr
Publication Language
eng