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Publication

Study of intracellular deposition of the anti-leprosy drug clofazimine in mouse spleen using laser microprobe mass analysis.

Abstract

Laser microprobe mass analysis (LAMMA) was used to study the composition of the brick-red crystalline material which had accumulated in the spleen of mice that had received the anti-leprosy drug Clofazimine in their diet for several months. The crystalline deposits light-microscopically resembled pure Clofazimine crystals. The presence of the drug in the crystals was indicated by LAMMA by the appearance of the chloride mass peaks in the negative mass spectra. More specific information was obtained from the positive mass spectra. A mass signal for the protonated molecule was present.

More information

Type
Journal Article
Author
Vandeputte D
Jacob W
Van Grieken R
Boddingius J
Year of Publication
1993
Journal
Biological mass spectrometry
Volume
22
Issue
4
Number of Pages
221-5
Date Published
1993 Apr
Language
eng
ISSN Number
1052-9306
DOI
10.1002/bms.1200220402
Alternate Journal
Biol. Mass Spectrom.
Publication Language
eng