01312nas a2200289   4500000000100000008004100001260001300042653001200055653001600067653002000083653000900103653001100112653001100123653002200134653000900156653002100165653001100186100001700197700001200214700001800226700001700244245012900261300001000390490000700400520060100407022001401008       1993                            d  c1993 Apr10aAnimals10aClofazimine10aCrystallization10aDiet10aFemale10aLasers10aMass Spectrometry10aMice10aMice, Inbred CBA10aSpleen1 aVandeputte D1 aJacob W1 aVan Grieken R1 aBoddingius J00aStudy of intracellular deposition of the anti-leprosy drug clofazimine in mouse spleen using laser microprobe mass analysis.  a221-50 v223 a<p>Laser microprobe mass analysis (LAMMA) was used to study the composition of the brick-red crystalline material which had accumulated in the spleen of mice that had received the anti-leprosy drug Clofazimine in their diet for several months. The crystalline deposits light-microscopically resembled pure Clofazimine crystals. The presence of the drug in the crystals was indicated by LAMMA by the appearance of the chloride mass peaks in the negative mass spectra. More specific information was obtained from the positive mass spectra. A mass signal for the protonated molecule was present.</p>  a1052-9306