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Serum Levels of Interleukin-1β and Interferon-γ in Hansen’s disease.

Abstract

Background: Hansen’s disease is a chronic infectious granulomatous disease caused by Mycobacterium leprae. In leprosy the final immune response depends on predominant effector pathway M. leprae bacilli are presented by antigen presenting cells to CD4+T cells with subsequent release of Interleukin -12 leading to TH1 response. Release of interferon gamma (IF-γ) promotes further TH1 response development. IF-γ along with tumor necrosis factor and IL-2 leads to recruitment of monocytes and their transformation into epithelioid cells and granuloma formation. Aims: Our aim of the study was to analyse serum levels of interleukin-1β (IL-1β) and interferon-γ in newly diagnosed untreated patients of leprosy and to co relate their levels with clinico-histopathological profile. Methods: (including settings and design and statistical analysis used). The study was an analytical cross-sectional study. Fifty newly diagnosed leprosy patients were included in the study. They are categorized into paucibacillary (30) and multibacillary (20) groups. Serum cytokines assay for IL-1β and IFN-γ were performed by ELISA and were compared between the two groups. Mean serum cytokine levels of IL-1β and IFN-γ in both paucibacillary and multibacillary groups were calculated. Significance of mean difference between IL-1β and IFN-γ was assessed using Mann Whitney U test between the two groups. Results: Significant high serum levels of IFN-γ were seen in paucibacillary group as compared to multibacillary group. Although serum levels of IL-1β were raised in multibacillary group compared to paucibacillary group. The mean difference was not statistically significant. Limitations: The limitation of present study is low sample size. Conclusions: Serum interleukin levels (IL-1β and IFN-γ) are different among the paucibacillary and multibacillary cases. The fact is useful not only to understand the disease pathogenesis but also in sub categorization of Hansen’s disease patients.

More information

Type
Journal Article
Author
Yadav S
Year of Publication
0
Journal
Annals of medical and health sciences research
Number of Pages
465-468
Language
eng
Publication Language
eng