@article{33100,
  author = {Yadav S},
  title = {Serum Levels of Interleukin-1β and Interferon-γ in Hansen’s disease.},
  abstract = {<p><strong>Background: </strong>Hansen’s disease is a chronic infectious granulomatous disease caused by Mycobacterium leprae. In leprosy the final immune response depends on predominant effector pathway M. leprae bacilli are presented by antigen presenting cells to CD4+T cells with subsequent release of Interleukin -12 leading to TH1 response. Release of interferon gamma (IF-γ) promotes further TH1 response development. IF-γ along with tumor necrosis factor and IL-2 leads to recruitment of monocytes and their transformation into epithelioid cells and granuloma formation. <strong>Aims: </strong>Our aim of the study was to analyse serum levels of interleukin-1β (IL-1β) and interferon-γ in newly diagnosed untreated patients of leprosy and to co relate their levels with clinico-histopathological profile. <strong>Methods: </strong>(including settings and design and statistical analysis used). The study was an analytical cross-sectional study. Fifty newly diagnosed leprosy patients were included in the study. They are categorized into paucibacillary (30) and multibacillary (20) groups. Serum cytokines assay for IL-1β and IFN-γ were performed by ELISA and were compared between the two groups. Mean serum cytokine levels of IL-1β and IFN-γ in both paucibacillary and multibacillary groups were calculated. Significance of mean difference between IL-1β and IFN-γ was assessed using Mann Whitney U test between the two groups. <strong>Results: </strong>Significant high serum levels of IFN-γ were seen in paucibacillary group as compared to multibacillary group. Although serum levels of IL-1β were raised in multibacillary group compared to paucibacillary group. The mean difference was not statistically significant. <strong>Limitations: </strong>The limitation of present study is low sample size. <strong>Conclusions: </strong>Serum interleukin levels (IL-1β and IFN-γ) are different among the paucibacillary and multibacillary cases. The fact is useful not only to understand the disease pathogenesis but also in sub categorization of Hansen’s disease patients.</p>
},
  year = {0},
  journal = {Annals of medical and health sciences research},
  pages = {465-468},
  url = {https://www.amhsr.org/articles/serum-levels-of-interleukin1-and-interferon-in-hansens-disease.pdf},
  language = {eng},
}