Reversal reaction in a borderline lepromatous leprosy patient after COVID-19 vaccine: Prevention or risks?

Reversal reaction in leprosy is an immunologically mediated response due to alteration of cell-mediated immunity associated in leprosy spectrum. In COVID-19 pandemic era, leprosy patient is susceptible to the infection. According to guideline, vaccination should be given to leprosy patients. This case reported a 33-year-old male with reversal reaction after COVID-19 vaccination. On examination, patient had erythematous plaque of the face, trunk and extremities, also multiple ulcers of the trunk and extremities. Treatment was commenced immediately with prednisone and second vaccination was delayed. Within our follow-up, marked improvement were obtained after 6 weeks.