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Resistance of M. leprae to Quinolones: A Question of Relativity?

Abstract

Multidrug resistant leprosy, defined as resistance to rifampin, dapsone and fluoroquinolones (FQ), has been described in Mycobacterium leprae. However, the in vivo impact of fluoroquinolone resistance, mainly mediated by mutations in DNA gyrase (GyrA2GyrB2), has not been precisely assessed. Our objective was to measure the impact of a DNA gyrase mutation whose implication in fluoroquinolone resistance has been previously demonstrated through biochemical studies, on the in vivo activity of 3 fluoroquinolones: ofloxacin, moxifloxacin and garenoxacin.

More information

Type
Journal Article
Author
Veziris N
Chauffour A
Escolano S
Henquet S
Matsuoka M
Year of Publication
2013
Journal
PLOS Neglected Tropical Diseases
Language
eng
Call Number
VEZIRIS 2013
Publication Language
eng