01132nas a2200193   4500000000100000008004100001653002600042653001200068653000800080100001400088700001600102700001500118700001400133700001500147245006900162856012200231050001700353520056800370       2013                            d10aMulti-drug resistance10aleprosy10aDNA1 aVeziris N1 aChauffour A1 aEscolano S1 aHenquet S1 aMatsuoka M00aResistance of M. leprae to Quinolones: A Question of Relativity?  uhttp://www.plosntds.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pntd.0002559&representation=PDF  aVEZIRIS 20133 a<p>Multidrug resistant leprosy, defined as resistance to rifampin, dapsone and fluoroquinolones (FQ), has been described in Mycobacterium leprae. However, the in vivo impact of fluoroquinolone resistance, mainly mediated by mutations in DNA gyrase (GyrA2GyrB2), has not been precisely assessed. Our objective was to measure the impact of a DNA gyrase mutation whose implication in fluoroquinolone resistance has been previously demonstrated through biochemical studies, on the in vivo activity of 3 fluoroquinolones: ofloxacin, moxifloxacin and garenoxacin.</p>