Back to search
Publication

Protective efficacy of BCG against leprosy in São Paulo.

Abstract

The case-control study reported here evaluated the protective effect of BCG vaccine against leprosy in São Paulo, Brazil. Seventy-eight patients under age 16 who had been diagnosed as having leprosy (cases) and 385 healthy individuals (controls) were selected and matched by sex, age, place of residence, and type of exposure to leprosy (intradomiciliary or extradomiciliary). The cases were drawn from an active patient registry and from a group of new leprosy cases treated at 50 health centers in the cities of Bauru and Ribeirão Preto in the state of São Paulo. In order to estimate the protective effect of BCG, the prevalences of BCG scars in cases and controls were compared. The presence of one or more scars was associated with an estimated protective efficacy of 90% (95% confidence interval: 78% to 96%). Stratified analysis by age group, sex, socioeconomic level, and clinical form of the disease revealed no significant differences in the protection provided by the vaccine. However, it seems clear that more data will be needed in order to accurately assess the true relevance of BCG for leprosy control programs.

More information

Type
Journal Article
Author
Lombardi C
Pedrazzani E S
Pedrazzani J C
Filho P F
Zicker F
Year of Publication
1996
Journal
Bulletin of the Pan American Health Organization
Volume
30
Issue
1
Number of Pages
24-30
Date Published
1996 Mar
Language
eng
ISSN Number
0085-4638
Alternate Journal
Bull Pan Am Health Organ
Publication Language
eng