Back to search
Publication

Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage.

Abstract

Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in a case-control study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy.

More information

Type
Journal Article
Author
Cardoso CC
Martínez AN
Guimarães PEM
Mendes CT
Pacheco AG
Oliveira RB
Teles RMB
Illarramendi X
Sampaio EP
Sarno EN
Dias-Neto E
Moraes MO
Year of Publication
2007
Journal
Journal of neuroimmunology
Volume
190
Issue
1-2
Number of Pages
131-8
Date Published
2007 Oct
Language
eng
ISSN Number
0165-5728
DOI
10.1016/j.jneuroim.2007.07.015
Alternate Journal
J. Neuroimmunol.
Publication Language
eng

More publications on: